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The predominant reported side effects were gastrointestinal symptoms. The incidence and pattern of side effects were similar in all age groups and did not appear to be related to dose over the range studied.
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These data confirm the favorable tolerability and safety profile Diflucan From India in other published studies of fluconazole used in children 4 — 8, 17, 18, 25, 26. Dosage recommendations for fluconazole in pediatric patients have been established on the basis of pharmacokinetic studies involving more than 100 children 1. The volume of distribution and elimination rate in pediatric patients differed significantly from the values reported for adults 2, 3. The volume of distribution varied with age, being greatest in neonates and decreasing by young adulthood to a value approaching that for adults.
With the exception of neonates, elimination was generally more rapid Diflucan From India children Diflucan From India in buaramoda.com with a mean plasma elimination half-life of about 20 h for all pediatric age Diflucan From India. In neonates and premature babies, however, fluconazole was eliminated slowly, with a mean elimination half-life of 88. Appropriate dosage recommendations for pediatric patients have been developed to ensure that the concentrations attained in the plasma of children are comparable to those seen in the plasma of adults receiving currently recommended dosages.
Although fluconazole is not metabolized extensively by the liver, hepatotoxicity is a potential concern, particularly in very young or premature infants with suboptimal liver function.
MATERIALS AND METHODS
Only three children 0. The data obtained in Purchase Hytrin 2 mg on the internet candidiasis, and pneumonia, optimal therapeutic dosage and duration of therapy have not been established. In open, noncomparative studies of small numbers of patients, Diflucan From India of up to 400 mg daily have been used. Urinary tract infections and peritonitis: For the treatment of Candida urinary tract infections and peritonitis, daily doses of 50 to 200 mg have been used in open, noncomparative studies of small numbers of patients.
The recommended dosage for treatment of acute cryptococcal meningitis is 400 mg on the first day, followed by 200 mg once daily. The recommended duration of treatment for initial therapy of cryptococcal meningitis is 10 to 12 weeks after the cerebrospinal fluid becomes culture negative.
The safety profile of fluconazole was assessed for children (ages, 0 to 17 years) comprising males and females. The data are derived from 12 clinical studies of fluconazole as prophylaxis or treatment for a variety of fungal infections in predominantly immunocompromised patients.
The recommended dosage of fluconazole for suppression of relapse of cryptococcal meningitis in patients with AIDS is 200 mg once Diflucan From India. Prophylaxis in patients undergoing bone marrow transplantation: The recommended fluconazole daily dosage for the prevention of candidiasis of patients undergoing bone marrow transplantation is 400 mg, Diflucan From India, once daily. Patients who are anticipated to have severe granulocytopenia less than 500 neutrophils per cu mm should start fluconazole prophylaxis several days before the anticipated onset of neutropenia, and continue for 7 days after the neutrophil count rises above 1,000 cells per cu mm.